I really don't see the M1 Garand being the ban list if such a list comes to pass. It doesn't use a detachable magazine, it isn't capable of holding more than ten rounds fully loaded, it doesn't have a pistol grip, a flash suppressor, or any other "evil" feature except a bayonet lug. The only way the Garand would fall victim to a ban if it was on all semi-automatics regardless of features. Plus, the CMP will send one right to your door for about $525.
I wouldn't suggest a M1 for indoor home defense, the .30-06 has way too much oomph and blast for indoor use (though obviously it could be pressed into service inside, it is far from ideal). However, as an overall defensive semi-automatic rifle it has plenty of utility.
I have a couple of ARs, so my Garand isn't really a defensive weapon for me, but I do have it available with a couple of loaded clips should push come to shove. I use a 9mm SBR AR with a suppressor for home defense, to me the blast from a 5.56mm is just too much for indoor defense use and I don't, as of yet, have a rifle rated suppressor.
I have always wanted Ruger to make a Mini-M1, you know, a 5.56mm that loads with a 10-round enbloc clip that ejects when the last round is fired. I'm afraid the only way that might come to pass is a new ban though.
If we are talking about a carbine for indoor use only, I'd also go with the .357 levergun recommendation.