jr45: I just searched the Hodgdon website for loading information for your 175 gr bullet in the 280 Rem. Unfortunately Hodgdon does not show that powder use for your bullet weight. Perhaps H4895 is a tad to slow for that heavy bullet weight. H4895 is shown for the 160 gr bullets however. I suggest you check the Hodgdon website for their recommended loads for your bullet. Good shooting.