I've owned a dozen or more Model 19's over the years. I still have two of them.
Now, I'll be the first to admit that I don't shoot them a lot, so I've never had to worry about wearing one out. But at the same time, I've never seen much sense in shooting high powered magnum ammo just to punch a hole in a piece of paper or to bounce a can around. The ammo costs more (even if I reload it), it kicks harder, and causes more wear and tear on the gun and my arm.
So I do most of my shooting with 38 Specials. And not even P+ 38, just plain old 38's (P+ will not hurt the gun however...they are WAY below the 357 threshold). They're not my carry guns. I don't hunt with them, and the paper I shoot doesn't take a lot of killing. I suppose if I was a cop and the Model 19 was my duty gun, I'd do it differently, but I'm not so I don't. I'd probably use an "L-frame."
I clean my guns at least fairly regularly so I've never had the problem with build-up in the cylinder. Nothing out of the ordinary cleaning, just cleaning. One thing that really helped was I stopped shooting plain lead bullets. Plated ones are a lot cleaner.