QuickLoad is great for rifles. I do not think that it takes cylinder gaps into account so I'm not sure it's that accurate for revolvers.
I largely agree with the above. It seems to be pretty accurate with 6" 38/357, but not so accurate with 2" snubbie loads. With the accurate line of powders, tends to predict low for snubbies with 2400, Blue Dot, Unique, Power Pistol, Bullseye.
I don't tinker with it much for pistols/revolvers, but I do like supplementing my manuals data for rifle loads. For example, 16" Ar-15, most load data is for 20" or 24" barrels, but I have a 16" carbine. It has been pretty accurate, usually within a SD of my load (W748, BLC2, AA2230, TAC, Varget) letting me know what I should expect over the chrono.
Note though, it can cause additional stress, like when you run some Barnes TSX data through it and they are way hot! This is true for several calibers and other powder/bullet data sources. Use it as supplemental information, but not as a substitute for multiple loading manuals and powder mfg data.
I've tinkered with it in 223, 30-30, 243, 308, and 30-06. I do like how it gives you the %fill of the case, assuming you have measure your case capacity in grains of H2O.
Overall, worth the investment if you're a numbers geek. Bottom line though, it's not going to replace shooting loads and checking for accuracy.