I think the Colt New Frontier 22's are the best .22LR single action revolvers ever made. I have one, as well as a Colt Peacemaker 22 (which is identical to the New Frontier 22 except it has fixed sights). Both the New Frontier and the Peacemaker 22 are roughly 7/8 sized and built on steel frames. The are light, comfortable in the handle and quick pointing. Young people and women seem to love them, though I like them, too, despite my large hands.
The Colt Scout 22's are similar, but are built on aluminum frames. While the New Frontier and Peacemaker 22's are case hardened and blued, the Scouts are painted. They look and feel sort of cheap to me.
I also have a Single Six (the 50th Anniversary convertible model that came out in 2003). I don't really care for it. It feels much bulkier and heavier than my Colts. It is much slower handling. It's also nowhere near as smooth, but that may be in large part due to the fact that my Colts were both bought used and had been worn in, while the Ruger was bought new and probably has less than a box of ammo through it.
I'm always looking for good New Frontier 22's at reasonable prices. They tend to be cheaper than the Peacemaker 22's, and have much better sights than either the Peacemakers or Scouts. I paid $350 about two years ago for the one I have, and it was in excellent condition with both cylinders but without the box.