No, because as we develop the skills to use firearms, we discover the wide variety of applications means we need other tools in different shapes and sizes.
If all you have is a hammer, then everything is seen as a nail. I don't use serrated face framing hammers on light household trim or jewelry box repair - conversely, I don't use 8mm sockets to remove 32mm axle nuts. .22's are nice but I wouldn't go looking for a silverback grizz in deep cover to finish him. Better the .3xx magnum to do the job right the first shot.
On the other hand, you can have too much. Taking the collections out previously mentioned to put 50 rounds thru them, lets pack up the .22, .32, .380, 9mm, .38, .357, 40, .45ACP, .45 Colt, and top off with a .50 AE. Nice for a collection, but a lot of overlap and expensive to shoot. Rifles are equally complicated.
And with that collection of handguns you would get SA, DAO, DA/SA, decocker, and mag safety too, and lets throw in the HK P7 grip cocker for fun. Is just one type of trigger all you need? Really limits the use, conversely, having them all means an much bigger expense being good at any of them. It seems the average poster is challenged to handle a DA/SA trigger, something cops used as normal equipment on S&W third generation guns.
Maybe we should only choose the most difficult because if we get good with that we are good with anything? No, I haven't found it easy to learn how to work on carburetors with a 1/2" drive impact gun. I can "download" it a whole bunch but frankly, a screwdriver would be more efficient and less troublesome with a compressor running and hose snaking all over the fenders and engine while it's running.
I know it's been a discussion of guns and cartridge being tools, but that is exactly what they are when we divorce the masculinity factor out of it. All they do is project power - so pick the one that projects enough power, but not too much. If you have flies on your target downrange use the best choice for the distance and power projection need. A normal fly at 100m? .22. A 36" fly? .375 Socom? 12 ga rifled slug? You sure want to get it before it gets you.
Some cartridge are better than just one, but not too many.