I'll second the opinion regarding heavier bullets for the 300 Win Mag. My favorite bullets are in the 200 grain family, usually Speer and Sierra. I won't go lighter than 180 grain bullets for this cartridge. I like Retumbo powder and Winchester Large Rifle Magnum Primers. Magnum primers are hotter than conventional primers. Not a different compound, just more of it. Large powder capacity cartridges generally call for slow burning powders and many load manuals will specifically call out a magnum primer to enhance the ignition process. Uniforming the flash hole in the brass is something you can do to ensure it is fully open and provides uniform ignition.
Fit check the new brass to your gun before loading it. I had an experience with my 7mm Rem Mag where new brass wouldn't chamber properly. I discovered it after I had loaded 20 rounds. Now I make it a point to full length size all brass the first time they are to be used. Neck sizing after they are fire-formed to the chamber extends brass life and will also help in the accuracy department.
Be aware, when you read max load for a specific bullet it means max load. The obvious consideration is that going above max load is dangerous to you and the gun but the other, lesser considered reason is, bullet integrity is not the same for all bullets. Under too high a charge the bullet can break apart in flight.