For me, I like to stick with a propellant that gives me a balance highest velocity, and highest load density w/o going compressed per the particular application. Also, should you go with H380 you might work up some loads using magnum primers. I always get better accuracy using them.
For some rounds i.e. .223, this almost means ball powder, and you get superior metering as a bonus if that matters.
H380 got its name because it is the charge (added a zero) B. Hodgdon used in his 22-250 getting one hole groups with 52 grain bullets and 38 grains of H380.