Just remember, you can handload a .458 Winchester Magnum down to the 1800 ft lbs of a .243, but you can't handload a .243 up to the roughly 5,000 ft lbs of the .458. For the handloader, it's always much more versatile to go bigger. There is no such thing as overkill. If moose or brown bear is on the menu, get a .338 and load it down to .35 Remington or .35 Wheelen levels for deer. Don't try to shoot brown bear with a .30-06. Don't listen to the hype. Get enough gun. JMHO. Of course, recoil does NOT enter my considerations when choosing a hunting rifle. If you can't handle the recoil of an adequate caliber for the game, don't hunt that game. Buy a .22 and be content with squirrel hunting. Don't chase moose with a .223.