It really comes down to equipment bullet design and shooter ability. If you aren’t using bullets that dump in the animal that still function at lower velocity then you’re depending on near perfect bullet placement to efficiently kill. No hydrostatic shock no fragments means perfect heart spine or head shot. Double lung shots at long range are gonna leave a ton of tracking with minimal blood. Average accuracy in the field under perfect conditions might be moa. If you’re moving around and the animals are moving around you can pretty much double that or more depending on your shooting discipline and how much your heart rate is elevated. Picture perfect shots are rare in the field. Maybe if your in the blind watching a bait pile or feeder at a known range and everything in your favor you could be confident at extended ranges but the reality is that if your actively pursuing and stalking and locating game you need forgiveness in shot placement and you need a bullet that is going to do the job properly.