Keep in mind that some of out members simply hate money.
O maybe it's a case of just being dumb.
For longer them some of them have been alive the Old Fuff has been able to partly support his gun buying habit by knowing what to shoot, and what not to.
If it's really unfired, an older Smith & Wesson revolver, especially an N-frame, and extra especially if it's an early model 27 or pre-27.... well it's like money in the bank, and better - particularly at today’s interest rates.
In this case the 3 1/2 and 5 inch barrel lengths are especially popular, and draw the most $$$$$. A box with papers and accessories will add substantially, but not having them won't reduce the basic value of the gun.
If you watch the larger collector auctions (and I don't mean ones like Gunbroker or Guns America) you would know, as I do, that classic and antique
high quality guns are going through the roof - even in the present down economy.
Shooting a perfect
unfired collectable will reduce it's value, and it's the collectors - not the I-shoot-everything-I-got crowd that have the desire,
and big bucks to pay for what they want.
On the other hand if what ever you have has already been used or shot some, the extra-high value of an unfired/unused piece is gone, and shooting it a bit more won't decrease the value enough to matter so long as the additional use is only occasional.
As for shooting antiques - using current smokeless cartridges in what was made to shoot black powder can reduce a valuable collectable to scrap, and if you break a spring or some other part, finding a replacement and a qualified gunsmith to fix it will likely prove to be expensive, and without a fix the value is substantially diminished.
On the other hand since I know how to repair some of these older guns I've taken some of the I-had-to-shoot-it-'cus-it-was-made-to-shoot guys to the cleaners after I bought the remains on-the-cheap because they had too do what they had too do....
So do what you want. But keep in mind that they're two kinds of people. Those that always buy what they have out-of-pocket, and those that buy using profits from what they buy. I'm way too smart to shoot everything I've got.