Looks like a few more votes for 2400. I'll pick some up and try it out.
ssyoumans - Have you chrono'ed 158 or 180gr with that set up?
I haven't tested any 180gr bullets. I have a box of Sierra's, but haven't ever loaded any up.
I have fired some upper-mid range 158gr LSWC's in my SP101.
12.0gr 2400 out of 3" SP101: 1081 fps, 410 ft-lbs
12.0gr 2400 out of 6" GP100: 1216 fps, 519 ft-lbs
So, the SP101 was 137 fps slower than the 6" GP100
Alliant's data says 15.3gr is Max (at least according to my copy)
I have gone as high as 14.0gr of 2400 out of the GP100 for 1391 fps (679 ft-lbs), 13.5gr 1335 fps (625 ft-lbs), 13.0gr of 2400 for 1290 fps (584 ft-lbs).
So, if I were extrapolating, I'd say 15.3gr of 2400 would get around 1525fps (806 ft-lbs) out of the 6" GP100, out of a SP101 would be around 1350 fps (640 ft-lbs). There is probably someone out there who has fired a max load of 2400 out of the SP101, but I haven't gotten around to it. Haven't tried a max charge of 296 either. I've settled on 12.0gr as a nice comfortable load for the 3" SP101. Due to reduced bullet resistance, you get a lot higher velocity when using lead bullets than Jacketed in the same weight. For max "power" and penetration, hard to beat the 158gr LSWC HP in a 357 Magnum.