you do not state what you are hunting, so i think most of us here are ASSUMING it is around the whitetail deer size of animal. i can tell you that i hunt with a 6" s&w 629 44 mag. i can also tell you that i have harvested a whitetail with a 6" 357 mag as well. the big two things about handgun hunting are....1) distance you are capable of accuratly shooting. and 2) the bullet has to be matched to the velocity of the cartridge, AND the game you are shooting. in my state, you can LEGALLY shoot a whitetail deer with a .380 automatic! no one in 1/4th of a right mind would ever do that, but it is legal. i suppose, if you were within 10 feet, AND could get a good clear brain shot, it should kill a deer in its tracks. but every moon and star in the universe would have to be aligned just right for that to happen. i think that either a 45 colt, or a 44 magnum, used within their effective range, would cleanly take a whitetail sized animal. i doubt that it would be a drt. but i think that they would do a good job. the 44 mag, if you are capable, would extend the range over a 45lc. but some people can only shoot effectively out to 20 yards or so. in that case, either would do just fine. right now, with open sights, i am a 30 yard guy. my eyes are a bit fuzzy,so i limit myself to what i know i can hit. my 44 mag WILL have a scope on it before season next fall!