The pressure won't hurt them so much as too much velocity. Plated bullets don't fair as well in revolvers as auto's either. They don't seem to like that "jump" into the forcing cone. I am sure the better the chambers line up, the less this matters, as well as the smoothness of the throats and forcing cone. I have a couple of revolvers that will shoot plated at 1200+ FPS with no problems, and a couple that can't go over 1050 to 1100 without problems.
As GP100man posted, .001 won't matter, they'll obturate and fill the throats/bore no problem. If the throats are undersized for the bore, it will destroy the integrity of the plated bullet, but hey, lead won't shoot that way either. If the throats are way oversized, it will be hard on them as well.
What velocities are you looking for here? They should work fine for a light (for a 500) load. Please let us know.
They are not going to handle full pressure/velocity in a .500. I am sure of that.