I started with Unique back in 1973, pounding out .45 Colt reloads on a Lee Loader. It's a good powder for cast bullet loads. Some find it dirty but I haven't. A tight crimp helps it burn cleaner. In the .45 Auto, that pretty much dictates a tight taper crimp (except for revolvers using the half-moon rings).
Interestingly, Unique is the only powder I've found to be sensitive in very cold weather. In cavernous cases such as the .45 Colt or .45-70, with mild to light loads, it burns poorly in very cold weather.
Thirty-some years ago, I loaded 6.5 grains of Unique over a 250 gr. lead bullet for a plinking round. Both the pistol and ammo were in the car trunk during a winter camping trip where temperatures reached 0 Fahrenheit during the night.
Both gun and ammo were very cold when fired. The first round went BLAP ... the second BOOM .. then a BANG and back to a BLAP.
Velocities were so inconsistent that I couldn't hit a tin can at 20 yards because the bullets were hitting the bottom of the stump or sailing over the can.
I learned after that to (A) Keep your ammo and pistol warm if possible, (2) Switch to Magnum primers for very cold weather and (3) Avoid Unique as a cold weather powder in large cases, when loading medium to light loads.
Anyway, you shouldn't have that problem in the .45 Auto, where the volume is much less than the .45 Long Colt case. I mention it as a matter of interest, in case you want to use Unique in other calibers.
Back to your original question:
Lyman No. 47 shows:
185 gr. Hornady jacketed hollow point
Start - 4.8 grs. 630 fps 7,800 Copper Units of Pressure (CUP)
MAX - 7.8 gs. 985 fps 17,800 CUP
Overall cartridge length: 1.175"
200 gr. Speer jacketed hollow point
Start - 4.0 grs. 604 fps 7,300 CUP
MAX - 6.5 grs. 927 fps 17,700 CUP
Overall cartridge length: 1.178"