The .270 Win is easy to buy loaded ammo for. Choice of 130 grain or 150 grain. If you're hunting woods, take the 150, or take a different caliber rifle. If you're hunting where shots are over 200 yards, take the 130s. If you're shopping for 30-06 ammo, you may be there a while, trying to decide which of the 8 or so bullet weights and which of the 4-5 brands/types of ammo to buy.
A couple of years ago, I couldn't find any decent .308 Win ammo for my buddy in any Maine stores, much less .22LR. Glad that era of hoarding is over!!!