I'ld put my money on one of those insane .45-70 deringers..
Many rifle caliber arms with extremely short barrels (just a little longer than the cartridge) do not actualy have the tremendous energy you would think. Those rounds from the factory come with powders designed to make the most from a longer barrel, often with slow powders or progressive burns meant to keep them at high pressure for a longer period of time in the barrel. The additional case capacity is also designed to allow them to generate additional energy for longer, a useless feature if max pressure is reached early on and the bullet then exits the barrel when there is still plenty of leftoever unnecessary powder burning afterwards
The the very dimensions of the round were not designed for such a platform, which means it will never even meet a fraction of its potential.
What that means is that while still a big round in a really short barrel, a lot less of the energy is created between the breech and the bullet, and more of it is turned into a large fireball and a lot of noise outside the gun.
That means they are often equal to some of the mid range handgun calibers, and not even in the realm of many of the big bore handgun cartridges.
There is a barrel length minimum for many rifle calibers, below which much of the powder does not get turned into energy because only some of it combusts before leaving the firearm. For some cartridges it is 6 inches, for some 8, for others 10 etc (they they continue to gain energy much longer than just the burn time, but that curve is less severe that the initial one.) You can vary it somewhat with different powders, but that can only work within the limitations of the cartridge.
So the difference between a 12 and 20 inch barrel for example is far less than between a 5-10 inch barrel with most rifle calibers. Those first inches are the most important.
You can't just replace it with much faster powders either, as most of the case capacity is wasted, and
if you try to use most of that large case capacity with fast powders it would exceed pressure design and explode. So you in fact have a much larger cartridge than necessary for that level of performance out of that length barrel. A waste all around.
That is why an actual round designed from the start as a powerful handgun round can often have more energy in such size barrels than a rifle caliber with standard rifle ammo. A .500S&W for example is more powerful than most rifle calibers would be from a short handgun length barrel, especialy a carry length barrel.
Even relatively fast burning shotgun powders in a wide shell (read more surface area near primer and faster ignition) needs ~8 inches with many factory loads before it finishes burning.
So a round in a shorter barrel than necessary to burn the powder will result in less energy, less recoil, larger fireball and possibly muzzle blast, and will waste most of the ballistics of that round.
I repeat there is a big difference when people cite a difference of a couple hundred feet per second between inches of barrel not involved in the burn process of a round, and those critical inches at the start which can cut the energy into a small fraction of the rounds potential.
Those later inches are just how much longer the pressure generate is being applied to the rear of the bullet. The initial inches though are how high the pressure is able to get to begin with, not how long it is applied.
If the round cannot even reach its designed pressure level, it is not even the same round, and you might as well just rename it something like .45 FCEW (Fireball Creating Energy Waster.) As your only options are to waste most of the cartridge capacity and use a faster powder for the same perfomance, or waste a ton of slow powder out the front in a large fireball.
So magnum handgun rounds tend to be more powerful from tiny firearms than even rifle rounds, especialy factory rounds, until you at least have the minimum barrel length necessary to contain the burn time and reach standard pressures. Otherwise you are just wasting powder for performance you could have achieved with lower quantities of faster powder, as loaded in pistol rounds.
The power of a cartridge is tied to its maximum pressure, its case capacity, and the width of the base of the bullet, with larger amounts of surface area putting that pressure to use quicker (why a low operating pressure shotgun still puts that low pressure to good use with a big heavy projectile.)
A short barrel limits the usefulness of case capacity as you will still reach maximum pressures before doing all that is possible with the space capacity. Meaning you might as well use a shorter round with hotter powder out of that length barrel.
The max pressure is the limiting factor on how much energy can be applied while it is in the barrel.
The bullet width is the limiting factor in how much surface that pressure is applied to in the time it is in the barrel. The bullet weight can be tailored to best meet that high pressure for the longest period of time without exceeding it.
The round's energy is limited by the weakest link in there.
Most rifle rounds are only vhastly more powerful than pistol rounds if they have time to burn sitting near thier maximum pressures while the bullet is speeding down the barrel. Thier high pressure levels and higher case capacity allow them to continue keep them at near maximum pressure for many more inches of travel than most a pistol rounds. Most pistol rounds release thier energy suddenly and only reach operating pressure for a fraction of the time a rifle round applies its energy to the bullet.
That means by the time thier bullets travel many inches they have been imparted with energy for a longer length of time as the cartridge continued to generate more pressure for several fold longer than a pistol, but they still have to travel those inches of burn to get there. Simply being a powerful rifle round does not make them powerful from any platform.