I have killed a lot of deer with both 30 – 06 and muzzle loaders. With the muzzle loader either .45 or .54 using a patched round ball, I never saw a difference in their ability to drop a deer. Shot placement is, of course, most important. I have found that the state of the animal is also a significant factor. If he is just wandering along, minding his own business when you put a ball through his lights, he will generally drop in his tracks. Of course a spine or head shot will also drop him in his tracks. I have seen that happen many times on game even with a .22rf. If the deer is on an adrenalin high when you hit him, he is going to run. On one hunting trip, I shot a deer that looked like he had just had an encounter with a bigger buck. He was prancing around like he was expecting more trouble. I was using my .30 – 06 with 165 gr. bullets, and hit him just behind the last rib as he was quartering away from me at about 125 yards. After I hit him, he took off running, and I had to track him over 200 yards. The bullet put a 2 inch diameter hole in his liver, destroyed both of his lungs, and clipped of the top of his heart. I found the bullet, mushroomed perfectly, under the hide on the off side. I can find no fault with that bullet performance. I did not get a chance for a follow up shot. I think the results would have been the same with a .50 cal. round ball.