If I could have only one powder for reloading handgun cartridges, it would have to be UNIQUE. Most reloading manuals have data for it in; 380 ACP, 32 H&R Magnum, 38 SPL (also +P / +P+), and 357 Magnum. However, since I do not have to stick with Unique I also use Bullseye and 2400. While there...