For defense against nasty critters, I would stick to 180 or 200 grain FMJ. Reason being is that most hollow point rounds are designed not only for terminal effectiveness on humans (read, not very thick targets) but also to expand at lower velocities than what the 10mm pushes. THe result is that driving such bullets as 155 grain XTP's or Gold Dot's at the ~1,500 FPS that the 10mm will results in poor penetration and fragmented bullets.
For human defense, I use 180 grain Golden Sabres loaded to 1406 FPS (5" tube). THe GS's actually perform pretty well at such velocities-much better than GD's. For critter defense, I use either 180 grain FMJ, 200 grain FMJ or 200 grain Hornady XTP's (about the only HP that gets over 12" of penetration). I drive the 200 grain XTP's at 1278 FPS.
And FWIW, running loads like the ones I've described all the time will batter your gun in relatively short order. For plinking and range use, I run 180 grain pills at 1100-1150 FPS.