I'll second that, Elk are bigger and you should use a bigger, better made bullet. PMC now loads barnes X bullets 180gr in there preminum line. The smallest I'll use is a 165 premium bullet. In fact I have the new 165gr Hornady Interbond's loaded in my '06. They chrono's at 2800 fps and +3" at 100yds is dead on at 300yds. Just incase I need to shoot across a clear-cut.
Just hit them in the right spot and you shouldn't have a problem
Good luck
Cajun
With a case of 150's, I'd practice, practice, practice from as many different positions as possible.