Measure:
The inside diameter of a 243 Win case is roughly the same as the inside diameter of a 45 Colt case.
But not the same, so I cross sectioned them for this post.
I just measured:
The 243 is .395" inside diameter.
The 45 Colt is .435" inside diameter.
Calculate:
The .243 Win SAAMI max average pressure is 60 kpsi. The proof loads are 1.3 to 1.4 times that = 78 kpsi to 84 kpsi.
The bolt thrust is then potentially
Force = pressure times area
F = 84 kpsi [ pi r squared]
F = 84 kpsi [ 3.14 ][.395"/2]^2 =10,294 lb
The 45 Colt in a Browning low wall proof pressure is then at least
P = F/A = [10,294 lb]/ [3.14][.435"/2]^2 = 69,265 psi proof pressure.
Max average pressure [at least for 45 Colt in Browning low wall] = proof/1.4 = 49, 475 psi max average pressure
What does it all mean?
The rifle can handle a lot of pressure.
I would suggest 24 gr H110, 250 gr XTP, 1.6" OAL, roll crimp into the cannelure, 22 kpsi, ~ 1500 fps from a 16.25" barrel.
The recoil will be hard.
Get a Limbsaver recoil pad.