Joe, I come into this world left handed. My Mother and Father decided, since this was a right handed world, that I must be right handed. They began to train me to be right handed and I write and predominantely use my right hand; that extends to shooting. The brain once it determines what it wants to be doesn't change, in other words, I am left eye dominant. Now as a matter of fact I can shoot left handed as well as I can shoot right handed. You don't find many left hand guns, rifles, shotguns, revolvers or pistols. So I fire a gun, unless I just want to fire left handed, right handed. I am left eye dominant and use my right hand. The man who is the range officer where I shoot tells me that I have the dangest natural ability and that I am as accurate or better than a lot of local LEO that he knows. I'M NOT BRAGGING! I can only answer your question from my experience and say that it causes me no problem. I am 53 yrs old, raised on a farm hunting and shooting since I was big enough to hold up a gun. Do what feels natural, let your left eye do the work. If you try to force the right eye to aim with you'll have trouble. I have told my children that shooting a gun is like pointing your finger. Don't think of the gun as an object in your hand but as a finger. You don't look at your finger and then point it at an object across the room; instead you look at the object across the room and hit it with your finger. I hope I'm making since. Regards P.T.