These discussions are funny sometimes. Someone asks what the best ********* is for hunting and people start throwing out information on cartridges or bullets at 1000 yards...which is great if you are hunting 1000 yards and probably 99.9% aren't.
A survey done a few years ago on Texas Hunting forum asked hunters what their typical shot distance was and what their longest and shortest shots were. Over 95% said their typical shot distance was 100 yards or less. That jumped to 97 or 98% when the distance was stretched to 200 yards. A 1000 yard hunting rifle sounds really cool, but very few people actually utilize them for that.
Most people's longest shots were under 400 yards.
No doubt if you are a Wyoming or Nevada hunter, your shots may be typically at greater distances. If you are a Maine or Louisiana hunter, they may be much less.
I have a buddy with a 6.5 Creedmoor because the 6.5 Grendel just would not give him the able to kill deer/hogs at greater distances. While that theoretically may be true, I have never seen him hit anything beyond 400 yards and quite honestly can say that I haven't seen him recover anything he hit beyond 300. So I guess if he could hit stuff at greater distances, the bullet would have the velocity and energy to do its job, but actually being able to intentionally hit stuff seems to be a critical factor to consider first, LOL.
Me? I mostly hunt at 100-200 yards and I hunt a LOT. Probably less than 5% of my shots are beyond 200 yards. I have made a few kills beyond 300 (<10, and the longest being 365 yards, IIRC), but none beyond 400 and I don't think I have attempted any beyond 400.
The little Grendel seems to work just fine within those distances. Pretty much every caliber on the list would as well or better at typical ranges that the vast majority of people are shooting. So when the "best" issue comes up for hunting and people start throwing out long distances capabilities, I have to figure that long distance capabilities are really a non-issue for most people because whatever choice they are using is likely quite effective much farther than they will ever use it.
Do I think 6.5 Grendel is the best overall? Nope. I do think it is the best for my needs, however.