I have used 200 and 225 gr. JHP and 210 gr. JSP's, along with full house charges of 296 / H110 for years. I tried a lot of lighter 180's for a few years, but 180's didn't do as well in terms of accuracy. These heavier loads have proved to be very good at long range, and from multiple revolvers, and a 44 mag. rifle also.
A Ruger SBH 10.5" barrel, that pistol doesn't have glass on it, but I've shot jack rabbits out past 100 yds. with little trouble before my vision went south. I traded that one for a pristine older Wingmaster, that I traded for a 6.5" SBH.
Now the 7 something inch SRH, Leupold glass, full house 296 loads has shot excellent groups at 100 & 200 yds., also been great on yotes out to 200 yds. with 210 gr. JSP's. On one particular memorable day, I shot a jack rabbit with my scoped SRH from around 150 yds., I laid my pack on the hood of my truck for a rest and drilled him. Turned right around that same day and center punched a coyote at a little over 200 yds., again, rested off the hood of my truck. Those were with the 210 gr. JSP's, Sierra's I believe.
And with the Marlin / Leupold rig, and some 225's was extremely accurate out to 200 - 250 yds.. I could pick off jackies all day long at 200+ yards. I basically stuff them with a full charge of 296, hasn't failed me so far.
Basically, you can't go wrong with a full house 296 / H110 load, topped off with a jacketed 200 - 225 gr. pill. I wouldn't personally waste your time on anything lighter than 200 grs. though, they just don't shoot as well as 200 through 225's. You definitely get higher velocity, but they haven't been as accurate for me.
GS