Never had a problem with the 45xx Smiths, or any of the double-stacks for that matter. I had a 669 that I put rubber pachmayr grips on. It was pretty fat, but still very comfortable. Most of the S&W autoloaders that I've owned or fired have had good trigger reach. A friend has a G21, and that thing is just too big for my hand. I can't keep a good grip on the thing.
Been wanting a 1066 S&W. I just don't have the budget for a gun purchase at this point. It'd be a shooter rather than for carry, because I prefer a more compact carry gun. Still, if I ran across a nice example in my local shop, it might be an "impulse purchase", though I'd be in the dog-house.