IF you decide to keep the 22-250, might consider bumping you choice up to a .270-only a little more recoil than the 25-06 and is effective for just about anything in NA...(same can be said for the 25-06 and the 7mm-08-I just could never warm up to the 7mm-08 though)
Of the choices you listed, I'd go with the 25-06 with the 22-250 or the .243 if you are set on having only one gun-the .243 will do both jobs just fine, but the .243 is a "compromise" for each job as well...but if you put the bullet where it is supposed to go on deer, you will have meat! And if you find the proper bullet for the yotes, you will have fur!
Good luck with your choice!
Dave