I have killed more deer "dead on the spot" with the .250 than any other caliber I've used. All bullets but one exited the other side of the animal, leaving a large hole in the hide.
Two deer went 100 yards after being shot. Both were hit a bit too far back, so it was my fault.
I used 100 grain Remington Core-Lokt factory loads, and then my reloads with the same bullet on all the deer. Midway and Midsouth Shooter's Supply sometimes have .250 brass available
My rifle is also a Ruger M77 lightweight. It is very accurate for three shots, then the light barrel heats and the group shifts.
I went out looking for a Savage M20 in .250 but the ones I found were all in .300 Savage. Savage evidently made some 110s in .250, but I've never seen one. I saw one in .257 Roberts yesterday and found it interesting. If it had been in .250 I'd have laid the plastic on the counter pronto.
The .250 is a great cartridge.