I still think something is not right.
How far away from the target are you when you are shooting 5 inches low? If you are close to the target, you may not get enough adjustment from an adjustable rear.
Do you have a tapered barrel?
Fits Mark II and III heavy barrel guns including 22/45 and Browning Buck Mark Pistols (except Challenge, 5.5 Target, and 5.5 Field).
I don't think the Hi-Viz is meant for a tapered barrel. I bet your new front sight is taller than your old front sight.
Given that I have swapped sight with no change and you have changed with a 5 inch drop something just seems wrong.
Keep us posted.