You are going to get a lot of different opinions. The amount of fouling, and therefore the need for cleaning and lubing, will vary with brand of powder, type of lube, and caliber.
I get maximum accuracy (smallest group sizes) when I clean the bore with a damp mop followed by a dry patch between shots using a lubed patched round ball. I get acceptable (for hunting) sized groups just using a liberally lubed patch on the ball between shots. If I am using a conical (no patch), accuracy falls off after three shots if I don't swab and re-lube the barrel.
This in a .54 Hawken using real black, not a substitute, and patches lubed with PAM cooking spray (canola oil).