38spl, 2inch, 148gr wadcutter mold, Winchester #209 primers (just regular old trap primers): 690-720fps.
45LC, 4 5/8, 255gr RNFP mold, Winchester Muzzle Loader Magnum primers: 470-500fps
45LC, 4 5/8, 255gr RNFP mold, Winchester #209: 430-460fps.
A couple of notes:
Seating depth has a huge impact on velocity, more so in larger cartridges, the difference between seating like a normal load and seating all the way against the primer in a 45lc is a 250fps difference, the closer the faster.
In the 38spl, if I seated the bullet against the primer, the widest spread in velocity in ten shots was 7fps. Even though there were air bubbles in some of the bullets, they flew at the same speed. 7fps is crazy constant considering my Hornady Critical Defense factory loads had a major spread of over 80fps.
At 20ft, firing from a couch with elbows on my knees, I shot a group of about 2 inches with the 45lc Uberti SAA fixed sights, I had about the same group firing weaver stance at the same distance using BVAC Cowboy loads. I was disappointed with myself but I think I may need to sand bag it to see if it is me or the gun. It's funny, I was going to adjust the front sight because it was shooting a foot to the left with the Cowboy loads, now it is shooting 8 inches low with the glue sicks, I need to shoot it more to see what is going on.