Guess it depends on where you are and what style of hunting you do too.
For example, in the Northeast, you're usually hunting dense woods (trees and tree stumps, bushes, branches, etc). Most guys "ambush" hunt for white tails and wait for shots well inside 100 yards. So usually here guys sigh in at 100 yards but they definitely get an idea of where the bullet is going at 50 and 75 yards.
If you're out further west and you have wide open spaces (hilly plains), then you might want to zero at 200 or more yards, or zero at 100 yards and see how much you need to adjust your hold to be dead nuts on at 200 or 300 yards. Cuz I'm such a lousy shot and I don't get to practice that much, I personally wouldn't be confident at taking game at more than 300 yards, but that's just me.
Don't forget to dope your slope if your shooting at an angle. I'm jealous, really.