Other than the need for a tool to pry up the take-down lever of the main spring housing and the reassembly of the gun when insterting the MSH back in, the Ruger MkI/II/III is really not as time consuming and doesn't require more attention as some others, IMO. The upper can be removed by rapping the back of the upper receiver on a lightly padded non-marring surface and can be re-installed by doing the same at the muzzle end.
Others like the Browning Buckmark require more tools and a re mor invovled to get to the same point ans the MkI/II/IIIs. A hex wrench to remove the bolts on the sight rib/top strap and a screw driver for the barrel set screw. The sight rib must be remove to remove the bolt. There is a plastic buffer in the recoil assembly that must be kept track of or it will get lost, the (at least) two sight rib bolts and thier conical spur washers and the barrel set screw must also all be kept track of.
The Beretta NEOS isa litle better as it used a finger friendly nut to tighten the barrel down instead of a screw.
The 5" P22 does have that barrel weight to remove but is otherwise, IMO, not too difficult. The problem after removing the barrel weight, though, is that since the front sight you'll very slightly shift your zero. (Not an issue with the 3".)
Higher end target .22s are an entirely different discussion. No easy take-downs their.