I don't think the question is silly. I agree that choosing a cartridge purely because it is efficient is a rather odd way to pick a firearm, but there is another side to the question.
Take Glocks, S&W revolvers, and Browning Hi Powers. In the first two types (Glock and S&W revolvers) the size of the firearm is directly tied to the cartridge size. The J-frame and K-frame revolvers are much better for a CCW than an L, N, or X frame. In each frame size there is a fairly small range of cartridge options. If you can squeeze the most efficiency out of a cartridge it often means it is as small in case size as is possible for the caliber and bullet weight range. This translates to being able to fit the cartridge into a smaller firearm.
This is especially true with the Glock 37. I know there is not much of a fan-base for the 45GAP cartridge, but I think it is also true that there is a big fan-base for 45cal handguns. Many people find the Glock 21 to be overly large in the grip area, and it is certainly a thick pistol as well - challenging to carry in anything other than a duty or open-carry holster unless you wear parkas year-round. The Glock 30 is much smaller, but still pretty thick. By taking the 45acp cartridge and shortening it to the 45GAP dimensions, Glock was able to fit the cartridge into the G17/G22 size platform and even offer the G39 - which is a pretty small 45cal handgun.
I mentioned the Hi Power. I've owned both the 9mm and the 40s&w versions and I think the 9mm version is perfection while the 40cal is nice but can't hold a candle to the balance and feel of the 9mm. I've often wondered what the limit would be on upping the velocity and/or diameter of the cartridge in the 9mm version of the Hi Power without having to change the slide thickness, frame size, ...etc. Could you fit a 38 Super into the Hi-Power, and what would that be like? I like 9mm, but more velocity or larger diameter would be nice without loosing the balance and pointability of the original package.
I know this is long-winded, but many of our current handgun cartridges were born in the black powder era or designed to match black powder cartridge performance. Some of these have way more case capacity than necessary. Consequently, many of our current handguns are designed around cartridge lengths that are needlessly longer then they need to be. I'd love to see a totally new cartridge/handgun pairing that wasn't based on a parent cartridge or bullet diameter, but on a more holistic vision grounded in current powder capability, bullet design technology, handgun ergonomics, and performance.
If you made it to the end of this dissertation, thanks for persisting. To sum up, I think questions related to cartridge efficiency can help lead to new cartridge and firearms development and that excites me.
Thanks