My "house gun" has the CT-305 grips on it, I prefer that for home defense so the user can have a full grip for maximum control. Also, the environment for home defense will likely be in the dark. The glowing red dot is especially confidence inspiring to my wife who doesn't shoot regularly.
I tried a set of 405's for my carry 642 and sold them after a couple of weeks. They conceal nice but there is not enough to grap on to, in my opinion. I also found looking for the red dot, instead of just point and pull the trigger, slowed me down. My feeling is the laser is no advantage during a typical three foot or less self defense scenario and beyond that distance you will have the time for traditional aiming with the sights.
So I installed the traditional three finger rubber grip, only cost $12 instead of $250. They don't conceal as well but I always carry my gun in a belt holster, so the 3/4 inch difference isn't a problem.