I have a Colt OM Target in .22 LR. I took off the Coltwood grips and put on Hogue rosewood grips. I pair it with my Colt M357 also with Hogue rosewood grips. The original grips for these two great revolvers are, of course, carefully stored away.
And RugerMcMarlin is right -- these revolvers are actually Pythons without the cosmetics, such as the barrel underlug.