I have to recommend buying used. There are EXCELLENT buys in used 22 wheelguns and that round puts very low stress on them when they're decent quality.
A surprising option is the High Standards. I had a chance to handle one recently that was built on a frame size similar to an S&W K-frame, 9-shot, 5" barrel. Well used but very tight, dating to the 1960s. Zero cylinder play in any direction at full lockup, hammerblock safety in good condition. Something like that with slight honest holster wear could be had for $200 or so and would be an excellent buy.
SP101s in six-shot 22LR configuration are...not common, but they're out there. They tend to fetch over $300 used, more depending on area.
K-frame S&W 22s aren't too common but do exist in reasonable numbers. Good guns. There's a target model that's supposed to be just awesome but will probably go for more bucks...I'm not an expert there...
Various Colt 22s are excellent guns, better than any DA 22 made today, but they're a bit...finicky and hard to find a gunsmith for. I would avoid those unless you're willing to do pretty serious research.
22 revolvers of the quality of old are just not being made anymore.