Settle for a 5" like a 1905 Colt .45 and it might be a little easier. You could use a Baer Monolith frame. Or remodel a Baer Monolith gun. That would save several steps but would add cost. And the 6" .38 just looks more Steampunk.
But for S80 you will have to extend the dust cover of a frame cut for the lawyer levers, Caspian, Colt, etc. Seems like a good move in a gun lacking thumb or grip safeties.
Although for a "range gun," I would not mind depending on the inertial firing pin and half cock. My .22 target pistols do not have firing pin obstructions or grip safeties, and the thumb safeties just doesn't get used.