PigPen: your 649-2 can take moderate amounts of +P ammo, within reason: the Cor-Bons are abnormally hot, and some of the +P+ was labeled such just so cops could *say* they weren't running 357s
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This thread is about people who have 38Spl guns weaker than yours. In YOUR gun, the Winny 158+P lead semi-watcutters are one of the best possible choices out there and so long as you can cope with the recoil, you need shop no further. I wouldn't do ALL of my shooting in those, but a few boxes of range familiarity in it and a cylinderful to cap off each shooting session won't hurt it any.
As "+P" goes, those are very moderate in terms of gun stress.
There are a small number of JHPs in 38+P that also work in snubbies - the Winchester 130grain Supreme +P is a good one, and and loads based on the 125 Gold Dot (Speer, Proload, Georgia Arms, Black Hills, others) are quite nice too - and Speer is about to upgrade the projectile to a 130 designed for snubby performance, and that'll rock. But JHPs stress the gun a bit more than soft lead so if the gun is "barely +P capable" such as yours, or my Charter Arms Undercover, sticking with those Winchester 158+Ps might have merit.
My answer, in a gun much like yours: practice mostly with normal-pressure lead, have the Win 158+Ps as my home D load, practice with it sparingly. When the new 130 Speers come out, I'll see how they handle and shoot, and see what the gell-testers have to say (
www.ammolabs.com and the like).