As a fellow southpaw, I haven't had any problems with my Taurus PT92. While it ejects to the right, it has never popped me on the head, dumped one down my neck, or laughed at me for being "different." It's ambi safety is easy to use, and if you prefer, the mag release can be switched to the other side. Personally, I like the release set for me to hit it with my left middle finger. Likewise, I don't have a problem hitting the slide release with my trigger finger. I am able to keep a firm grip on the pistol, just reach up and snap the slide release, and back in the action.
FYI, I've only had one left-hand gun in over 20 years of shooting - a LH Savage 110 in .270 Winchester. To be honest, I have been so conditioned to the action on the right, I could never get used to it. Great gun and a great value (I think about $350 at Wal-Mart) and it could SHOOT.
I don't have much of a problem with "right hand" guns. Don't make a big deal out of it...just shoot them!!! A few hours of practice, and I think he might find controls on the left side of the gun - with the exception of a safety - to not be a big problem
Q