Big Mike,
If you can find one of the CAI imports grab it and run. Great piece, good balance, and factory grips can handle 357recoil nicely. Usually found at below market prices in SE PA. Got mine couple weeks ago and like it more and more each day. Required alot of dry firing and some Tetra lub to smooth out the DA trigger pull, but it's comming along nicely. Carries well in a good belt slide or pancake, assuming your nik reflects your true size.
For street use (CCW) any brand name 125gr 357Mag HP should work with Corbon being the current favorite among those who should know. However, for home defense use you might want to consider the new Speer 135gr+p 38Spl HP's that the NYPD has recently adopted or the Rem Golden Saber 125+P 38's. I shoot on an indoor range and don't see myself using 357mags at home, or anywhere else, without muffs and plugs. Plus I'm slower & less accurate with Mags vs. 38+P's in rapid fire.
All of the above is just my experience and $.02 worth. IMHO, unless you live in one of the occupied territories, $300 should get you a great all around firearm, a carry holster, enough ammo to figure out the sights, and one box of carry loads left over. Ya can't beat a deal like that that with a big stick.
Good Luck,