Bullet setback was one of the reasons I switched from .40S&W Golden Sabers to 45ACP Golden Sabers as a carry load. A low pressure round like .45 won't be as much of a problem with the higher pressure caused by bullet setback. Oddly, my 230gr .45 rounds don't even seem to even be as susceptible to setback as my 165gr. 40S&W rounds were anyway.
With revolvers, setback is a non-issue.
However, if you aren't re-chambering the same round in a semi-auto over and over, the ammo will be fine for a long, long time if you keep the loaded mags in a cool, dry place. Don't oil the magazines (oil will kill the primers).
Also, Chrome Silicon magazine springs are said to last better under a constant load. Might not be a bad idea to find a set for your mags.
In carry guns, the ammo should be rotated periodically (maybe every 6 months). The gun will be moving through various temperature conditions, be subjected to humidity and the constant movement could wear down the powder.