I've loaded gobs and gobs and gobs of .38's for my wife and I to shoot in CAS. I load a 130 gr. cast RNFP and a 160 gr. SWC and they're loaded in .38 cases, but to an o.a.l. that's nearly that of a .357 so they'll feed in her Rossi, so for all practical purposes, they're being loaded in .357 cases. It's a very light load of either Clays or Red Dot. Due to the nature of CAS, we shoot with the muzzles at varying angles, but usually more downward than anything. I've used every brand of primer under the sun, but currently am using Tula lead-free as that's all Graf's had in stock at the end of last year. Have never, ever once had a squib or a bullet stuck in a barrel on either revolver or more importantly the rifle.
I shoot copious amounts of Unique in my .38's .357's and especially my .44 Specials...my 4 lb. keg is almost empty. I load straight from either an RCBS UniFlow or Lyman No. 55 powder measure. Unique isn't the best metering powder out there, but variations in thrown charges are hardly enough to cause squibs in any of the mentioned calibers.
Although everyone here has made some good suggestions, but I believe your problem lies elsewhere:
I have a Uniquetek precision baffle.
I'd bet a dollar to a donut hole that this is your problem. A few years ago I was shooting lots of skeet and sporting clays with a 20 ga. and was loading my shells on a MEC Grabber progressive loader. I had used a 12 ga. Grabber years before when I was on our 4-H trap team and never had a single problem with squibs out of thousands of rounds. Same with the 20 ga. at first. Then at one point I ordered and installed an adjustable powder and shot bar which I checked with a powder scale when I first installed it. At the same time, I installed a powder baffle.
I immediately began getting squibs to the tune of a least 1 per 25 shells, sometimes two or three. I checked and re-checked the powder and shot charges being dropped by the bar, but the squibs kept on. As a last resort I removed the powder baffle and to this day have never had another squib.
I likewise had one of the Uniquetek baffles in my UniFlow, but was getting inconsistent charges when I'd throw and weigh charges for rifle cartridges. I finally removed the baffle. Problem solved. I can't explain why this happened and I know that countless thousands of folks are using baffles with no problems.
Remove the powder baffle and I'll guarantee you your problems will go away.
35W