I've used loctite on lots of applications. Tis better to drop a dab of blue loctite on the screw and not try to torque it down so tight in aluminum alloy threads, than to strip out the threads. Having worked on motorcycles all my life, I have some experience with aluminum threads. Unfortunately, they don't make helicoil kits as small as a revolver screw. I've never had a problem with mine, though, never laid a screw driver on it in some 6K rounds. I've got one M85UL and two M66s that are fantastic. I had a M19 Smith that was so, so accurate and I sold it. My only regret is that on the used market, I could have gotten TWICE what I paid for it in the first place if I'd hung on to it until now. I just didn't care much for the lack luster accuracy of the thing with .38 loads. My 4" Taurus will put those wadcutter loads into a little 1" cluster at 25 yards and will do the same with 140 grain .357 magnums using a Speer bullet. Out of four different brands/models, the Taurus is the most accurate and I shoot it a lot. So far, it's given me nothing to complain about.