Poohgyrr and Series70, I like your style!
Me, it's a bone stock S&W 642 Airweight .38 Special in the right front pocket most of the time (158-gr. +p and a Bianchi Speed Strip), or a customized Series 70 Colt Combat Commander (nearly all Ed Brown parts except for slide, frame, and barrel) in .45 ACP on an OWB holster (Blade Tech kydex, Galco leather single mag. carrier, new Wilson mags., Galco gun belt) loaded with 230-gr. Golden Sabers or HydraShocks.
And ALWAYS a Benchmade full-sized AFCK, non-serrated, in Black Ti.
And sometimes a Fox Labs pepper spray.
FYI, when I run, I wear a small backpack, so none of this stuff feels heavy when worn day-in and day-out.