Ackley Improved
cartridges get the most out of your rifle, in terms of velocity. But you pay for it. Special dies, fire forming brass, etc. If a slight gain in performance is worth the hassle, go ahead. A plus is that one can usually fire factory ammo as well (which also fire forms the case).
Today, if you want a significant performance increase, you are better off going to a different cartridge. Also be aware that a "custom" chamber can actually lower the market value of the rifle. Now a days, only a handful of folks want the exotics.
I wouldn't pass on a nice rifle because it was Ackley Improved, but I wouldn't go out of my way to find one either. They belong to an earlier era of rifle smithing, one where choices were much more limited, especially in ammo performance.
On the other hand, it does give you a semi custom rifle, one that not very many people are going to have. And today, not many people even know about. A good friend had an Ackley Improved .257 Roberts. It was a fine rifle. But while close, it wasn't a .25-06.