250 takedowns have a bit of panache about them but really the solid frames are better in terms of accuracy and durability, If you are really throwing a 100 rounds a week thru that gun, consider that the threads of the takedown h ave a thousandth or so gap to allow you to hand turn it off and that much shooting is wearing down a fair amount, The takedown model was for the train riding sportsman who wanted to get from his city locale to the country without causing much ado. The design is wonderfully simple using both solid and interrupted threads as time went on.
The two best rounds in the Classic 99 savage for deer are the .250 and .300 savage. Others available are the 30-30, the 38-55, the 32-40. the 303 savage, and the .22 hipower imp. Later versions were stretched to accomodate the .243, the .308 and the .358. (there may be a couple I am missing but this is the bulk) The .308 case family is longer than the earlier cartridges and necessitated some re-engineering to make them fit. Although on the grounds of modernization it was considered a good thing, the changes altered the feel of the gun and the action movement was longer. In practical matters, in it's intended use, the longer cartridges add nothing, the .250 is a better deer killer than the 243, the .300 works just as good as the .308 and the one cartridge that would have been better was the .358 which no one bought.
IMHO, there exist no better rifle for northern and wooded deer than the 99 savage, longer range than a 94 winchester, just as smooth to handle and just darn fine good looking guns.