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I usually can blow a tiny .284 inch hole one side and a softball sized hole (blasting massive amounts of blood) out the other with 150 grain Prvi Partizan Spitzer softpoint boat tail bullets and 54.4 grains of H4831sc out of my Remington 700 in .280 Remington moving about 2600 fps. I'd assume a similar sized and constructed bullet out of a .330-06 would do similar damage (but with a .30 entry hole)