No experience with the PX4, but I do have a 92FS. It is one of the easiest racking guns I have as well as soft shooting. Something to consider for women. If your wife can handle the grip, then it may be a good choice for her, and you as an HD pistol. They are very reliable, proven, and accurate guns.
That being said, the PX4 seems like a winner also, and the rotating barrel action intrigues me. Try to shoot both if you can but I don't think you can go wrong.