First of all, I don't load anything but jacketed, so anything I have to say will be based on jacketed bullets, and full tilt self defense data and results.
I load and shoot 90 gr. XTP's, 115 gr., 124 gr., and 147 gr.. Most all my loads consist of Longshot and CCI 500's.
I do most of my shooting at distances ranging from 15' to 15 yds., But the bulk of my practice is between 5 yds - 10 yds. with pistol. Slightly different story with my revolver practice routine though.
As for accuracy, I really can't see much, if any difference between bullet weights at those distances. Using a 6" target, I have no problem keeping most of my hits in the center portion of the target, regardless of the bullet weight I'm shooting.
The best way to tell what works for you, is to just start trying different load combinations, see what they do for you in terms of accuracy, or what ever criteria you are focused on. I personally love reloading, so trying different components has always offered an opportunity for me to load and shoot more. And even though I only load jacketed and mostly with Longshot, I have been reloading for more than 30 yrs., so that said, I have tried many different powders, load intensities, and firearms. And it's the result of all those years of different load developments that I have settled on Longshot. However, I do have other powders that I would use in a heart beat if L.S. suddenly became unavailable.
So as the great RC would say, shoot em Lizabeth, I think that's how he says it?
GS